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Early switch therapy from ceftriaxone to ampisilin in an immunosuppressed patient with Listeria monocytogenes septicemia and meningitis [Turk Hij Den Biyol Derg]
Turk Hij Den Biyol Derg. Ahead of Print: THDBD-04127

Early switch therapy from ceftriaxone to ampisilin in an immunosuppressed patient with Listeria monocytogenes septicemia and meningitis

Gülşen Hazırolan, Gulcin Dizman
Early switch therapy from ceftriaxone to ampisilin in an immunosuppressed patient with Listeria monocytogenes septicemia and meningitis

Listeria monocytogenes, yaşlılarda veya predispozan koşulları olan bağışıklık sistemi baskılanmış hastalarda enfeksiyona neden olabilecek önemli bir patojendir. Bu bakteri, bağışıklık sistemi baskılanmış kişilerde hayatı tehdit eden bakteriyemi ve meningoensefalitin önemli bir nedeni olabilir. Bu raporda, larenks adenoid kistik karsinomu olan 39 yaşındaki bir kadın hastada L. monocytogenes’in etken olduğu sepsis ve menenjit olgusunu tanımladık. L. monocytogenes’in tür düzeyinde tanımlanması matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS, Bruker, Almanya) ile yapıldı. Hasta tedavide seftriaksondan ampisiline erken geçiş ile tedavi edildi. Bu rapor, Listeria sepsis ve meninjitinin erken saptanmasının ve tedavisinin, daha iyi bir prognoz elde edilmesi için önemini işaret etmektedir.

Keywords: Listeria monocytogenes,, meningitis, septicemia, MALDI TOF MS


İmmün sistemi baskılanmış hastada Listeria monocytogenes’e baglı septisemi ve menenjitin tedavisnde seftriaksondan ampisilin'e erken geçiş

Gülşen Hazırolan, Gulcin Dizman
İmmün sistemi baskılanmış hastada Listeria monocytogenes’e baglı septisemi ve menenjitin tedavisnde seftriaksondan ampisilin

Listeria monocytogenes is an important pathogen that may cause infection in the elderly or in immunocompromised patients with predisposing conditions. It can be an important cause of life-threatening bacteremia and meningoencephalitis in immunocompromised individuals. In this report, we describe a case of sepsis and menegititis caused by L. monocytogenes in a 39-year-old female with adenoid cystic carcinoma of the larynx. L. monocytogenes identification was performed at the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS, Bruker Daltonics, Germany). The patient was treated with an early switch therapy from ceftriaxone to ampicillin. This report indicates that early detection and treatment of Listeria sepsis and meningitis are important to obtain a better prognosis.

Anahtar Kelimeler: Listeria monocytogenes,, menenjit, sepsis, MALDI TOF MS




Corresponding Author: Gülşen Hazırolan, Türkiye


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The Turkish Bulletin of Hygiene and Experimental Biology (Türk Hijyen ve Deneysel Biyoloji Dergisi) is double blind peer review, indipendent, international, Turkish and English-language, online and open-access, designed for scientists.


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