ISSN: 0377-9777 / e-ISSN: 1308-2523
Survival of rats with Walker 256 Tumor after oral suplementation of arginine in the diet [Turk Hij Den Biyol Derg]
Turk Hij Den Biyol Derg. 2012; 69(4): 225-228 | DOI: 10.5505/TurkHijyen.2012.48344

Survival of rats with Walker 256 Tumor after oral suplementation of arginine in the diet

Maria Rita Carvalho Garbi Novaes1, Fabiani Lage Rodrigues Beal2, Roberto Cañete Villafranca3
1Professor And Researcher. School Of Medicine. Escs/fepecs. Brazil
2Nutrition Institute. Catholic University, Brasilia, Brazil
3Professor And Researcher. Centre Of Hygiene, Epidemiology And Microbiology. Matanzas City, Cuba. Cuban Institute Of Gastroenterology. Havana City, Cuba

OBJECTIVE: This study was undertaken to assess the effect of L-arginine at 8% on extended survival of rats with Walker 256 tumor.
METHODS: The study is experimental, randomized, double blind. The animals for this experiment were divided in 3 groups. The first group (placebo) received gavage with water, seven days before the inoculation of Walker 256 tumor. The second group received 8% L-arginine solution of caloric ingestion 48 hours after the tumoral inoculation. The third group received 8% L-arginine solution of total caloric ingestion, initiated seven days before the tumoral inoculation.
RESULTS: The third group, supplemented seven days before the tumoral inoculation, presented greater extended survival (21 days, p=0.0001) when compared to animals from the other two. Animals supplemented 48 hours after the tumoral inoculation presented greater extended survival (20 days, p=0.0001) when compared to the placebo group (19 days, p=0.0001).
CONCLUSION: The results suggest that both groups supplemented with 8% L-arginine presented beneficial results in respect to extended survival when compared to the placebo group, and better yet if the amino acid was administered before the tumoral inoculation.

Keywords: arginine, cancer, survival, Walker 256 tumor.

Maria Rita Carvalho Garbi Novaes, Fabiani Lage Rodrigues Beal, Roberto Cañete Villafranca. Survival of rats with Walker 256 Tumor after oral suplementation of arginine in the diet. Turk Hij Den Biyol Derg. 2012; 69(4): 225-228

Corresponding Author: Maria Rita Carvalho Garbi Novaes, Brazil
Manuscript Language: English
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